The Three Horseman of Women's Health

The Three Horsemen of Women’s Health: Sermorelin, HRT, and GLP-1s | The Vagina Doctor Podcast/The Women's Health Edit with Sophie Mengele

Nurse practitioner Sophie shares her “three horsemen” of women’s health: Sermorelin, hormone replacement therapy (HRT), and GLP-1s, and explains how they fit together. She describes Sermorelin as a synthetic analog of the body’s natural growth hormone that declines with age and may help maintain muscle and prevent wasting associated with sarcopenia; she notes it was previously FDA approved for HIV patients with severe muscle loss. Sophie explains that GLP-1s support weight loss but can also lead to muscle loss, so Sermorelin is sometimes combined with GLP-1s to help counter muscle wasting, or used alone for those focused on preserving muscle without losing weight. She also highlights patient reports of improved deep sleep with Sermorelin. Finally, she emphasizes HRT as the foundation for replacing estrogen, protecting bones, and sometimes adding testosterone to support libido.

00:00 Three Horsemen Intro

00:30 Sermorelin Basics

00:55 Muscle Loss and Aging

01:38 Pairing With GLP-1s

02:51 Sermorelin Sleep Benefits

03:27 HRT Foundation

03:34 Wrap Up and Benefits

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