From Salmon Sperm to Surgery: Cutting-Edge Regenerative Therapies
Oculoplastic Surgeon Lyndon Doss on PDRN, Microneedling, Lasers, Exosomes, and the Future of Surgery
Duncan Turner, MD interviews Santa Barbara oculoplastic surgeon Dr. Lyndon Doss about modern shifts from traditional cutting-and-lifting surgery toward regenerative approaches, including injectable PDRN (“salmon sperm”), placenta extract, microneedling, and selective laser resurfacing. Doss explains causes and treatment differences for under-eye dark circles, emphasizing thin skin and the roles of collagen versus elastin, and contrasts cold microneedling and pico lasers with heat-based devices that can damage elastin and promote scarring. They discuss scar-minimizing protocols after brow lifts, surgical precision in blepharoplasty, and why laser blepharoplasty is inferior to blades and needle-tip cautery. The conversation covers skepticism about fillers and “biostimulators,” evolving canthoplasty techniques, concerns and possibilities for robotic surgery, fat grafting challenges and nano-fat, the regulatory uncertainty around exosomes, and longevity/skin topics including rapamycin and antioxidants.
00:00 Welcome and Introductions
01:06 Why Eyes Matter in Menopause
01:48 Regenerative Shift in Surgery
04:15 Surgeon Culture and Cutting
07:57 PDRN for Dark Circles
13:20 Microneedling and Scar Blending
16:21 Elastin Versus Heat Devices
19:05 Pico Lasers and Resurfacing
21:46 Placenta Extract Aftercare
22:52 Robots and Surgical Tactile Skill
31:24 Laser Bleph Limits
34:00 Filler Fatigue and Healing
37:41 Biostimulators and Muscle Devices
41:56 Collagen and Elastin Supplements
42:47 Marine Collagen Night Routine
43:15 Elastin Supplements and Sourcing
43:45 Heavy Metals in Supplements
44:32 Peptides Versus Proteins
44:53 EGF Myths and Wound Healing
49:08 Placenta Extract for Healing
50:28 Exosomes Basics and FDA Issues
53:33 Exosomes in Real World Healing
54:51 Fat Grafting Challenges and Cysts
01:02:44 Nano Fat and Stem Cell Boost
01:04:19 Measuring Eye Rejuvenation Outcomes
01:05:45 Canthopexy and Fox Eye Surgery
01:10:19 Rapamycin for Skin Longevity
01:13:36 Eye Aging and Facial Hollowing
01:15:39 Antioxidants for Retinal Health
01:17:11 IV NAD and Glutathione Skepticism
01:18:13 Closing Thoughts and Thanks
